Circulating levels of 3-hydroxymyristate, a direct quantification of endotoxemia in non-infected cirrhotic patients.
Fiche publication
Date publication
juin 2018
Journal
Liver international : official journal of the International Association for the Study of the Liver
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DI MARTINO Vincent, Dr LAGROST Laurent, Dr PAIS DE BARROS Jean-Paul, Mme LAHEURTE Caroline
Tous les auteurs :
Weil D, Pais de Barros JP, Mourey G, Laheurte C, Cypriani B, Badet N, Delabrousse E, Grandclément E, Di Martino V, Saas P, Lagrost L, Thévenot T
Lien Pubmed
Résumé
The quantification of lipopolysaccharide (LPS) in biological fluids is challenging. We aimed to measure plasma LPS concentration using a new method of direct quantification of 3-hydroxymyristate (3-HM), a lipid component of LPS, and to evaluate correlations between 3-HM and markers of liver function, endothelial activation, portal hypertension and enterocyte damage.
Mots clés
3-hydroxymyristate, bacterial translocation, cirrhosis, endotoxaemia, lipopolysaccharide, portal hypertension
Référence
Liver Int.. 2018 Jun 22;: