The Nuclear Bile Acid Receptor FXR is a PKA- and FOXA2-Sensitive Activator of Fasting Hepatic Gluconeogenesis.
Fiche publication
Date publication
juillet 2018
Journal
Journal of hepatology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr CIANFERANI Sarah
Tous les auteurs :
Ploton M, Mazuy C, Gheeraert C, Dubois V, Berthier A, Dubois-Chevalier J, Maréchal X, Bantubungi-Blum K, Diemer H, Cianférani S, Strub JM, Helleboid-Chapman A, Eeckhoute J, Staels B, Lefebvre P
Lien Pubmed
Résumé
Embedded into a complex signaling network coordinating glucose uptake, usage and production, the nuclear bile acid receptor FXR is expressed in several glucose-processing organs including the liver which synthesizes, stores or mobilizes glucose according to the organism's needs. Dysregulated in type 2 diabetes, hepatic gluconeogenesis (GNG) is controlled through allosteric regulation of gluconeogenic enzymes and by glucagon/cAMP-dependent transcriptional regulatory pathways. Whether FXR positively or negatively regulates fasting hepatic gluconeogenesis is still debated.
Mots clés
Bile acid, FOXA2, FXR, Glucagon, Gluconeogenesis, Liver, Nuclear receptor, PKA, Transcription
Référence
J. Hepatol.. 2018 Jul 4;: