Gastrointestinal manifestations of systemic sclerosis.
Fiche publication
Date publication
août 1994
Journal
Seminars in arthritis and rheumatism
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUILLEMIN Francis
Tous les auteurs :
Abu-Shakra M, Guillemin F, Lee P
Lien Pubmed
Résumé
Gastrointestinal (GI) manifestations of systemic sclerosis (SSc) were found in 82% of 262 patients followed up prospectively. Esophageal dysmotility, lower esophageal sphincter laxity, bacterial overgrowth, and wide mouth diverticuli were the most common findings. The disease is usually diffuse with multiple levels of involvement. Gastrointestinal involvement was not significantly correlated with gender, age at SSc diagnosis or disease type (limited or diffuse scleroderma). Upper GI symptoms develop early in the course of SSc and may not correlate with objective findings. Various investigations, treatment regimens, and less frequent disease manifestations are reviewed and discussed.
Mots clés
Adult, Deglutition Disorders, etiology, Female, Follow-Up Studies, Gastroesophageal Reflux, physiopathology, Gastrointestinal Diseases, complications, Gastrointestinal Motility, physiology, Heartburn, drug therapy, Humans, Male, Middle Aged, Prospective Studies, Scleroderma, Systemic, complications
Référence
Semin. Arthritis Rheum.. 1994 Aug;24(1):29-39