New glycosylated porphyrins for PDT applications.
Fiche publication
Date publication
janvier 2003
Journal
Oftalmologia (Bucharest, Romania : 1990)
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BARBERI-HEYOB Muriel, Dr FROCHOT Céline
Tous les auteurs :
Frochot C, Di Stasio B, Barberi-Heyob M, Carre MC, Zwier JM, Guillemin F, Viriot ML
Lien Pubmed
Résumé
A good sensitizer for photodynamic therapy (PDT) should be a very selective reagent, which should fastly eliminate from healthy tissues. Furthermore it should have a strong absorption in the red light and good energy transfer properties to molecular oxygen to produce singlet oxygen. All these specifications imply that many second generation photosensitizers (porphyrins, chlorins, bacteriochlorins...) have been modified in order to improve their properties, but however, few have received the approval by regulatory authorities. One way to increase the selectivity of a photosensitizer is coupling it to a vector. Carbohydrate-bound porphyrins were found to be of great interest because of the specific affinity of particular carbohydrates for some tumour cells, the increasing of plasmatic life time and solubility. In this study, we report the synthesis and the photophysical properties (absorption, fluorescence, singlet oxygen formation) of new glycosylated porphyrins. Then, in vitro photocytotoxic properties were evaluated on the human colon adenocarcinoma cell line HT29.
Mots clés
Computer Graphics, Drug Screening Assays, Antitumor, Glycosylation, HT29 Cells, Humans, Photochemotherapy, Porphyrins, chemical synthesis, Spectrometry, Fluorescence
Référence
Oftalmologia. 2003 ;56(1):62-6