Engineering the mouse genome by site-specific recombination.
Fiche publication
Date publication
octobre 1999
Journal
Current opinion in biotechnology
Auteurs
Membres identifiés du Cancéropôle Est :
Dr METZGER Daniel
Tous les auteurs :
Metzger D, Feil R
Lien Pubmed
Résumé
Site-specific recombination systems are powerful tools for introducing predetermined modifications into eukaryotic genomes. Recent advances allow the manipulation of chromosomal DNA in a spatially and temporally controlled manner in mice, offering unprecedented possibilities for studying mammalian genome function and for generating animal models for human diseases.
Mots clés
Animals, Chromosomes, Gene Silencing, Genetic Engineering, methods, Genetic Vectors, genetics, Genome, Integrases, genetics, Mice, Mice, Transgenic, genetics, Mutagenesis, Mutagenesis, Site-Directed, Recombination, Genetic, Viral Proteins, Viruses, genetics
Référence
Curr. Opin. Biotechnol.. 1999 Oct;10(5):470-6