Clinical randomized study of 5FU monitoring versus standard dose in patients with head and neck cancer: preliminary results.
Fiche publication
Journal
Anticancer research
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BARBERI-HEYOB Muriel, Pr CONROY Thierry, Pr MERLIN Jean-Louis
Tous les auteurs :
Fety R, Rolland F, Barberi-Heyob M, Merlin JL, Conroy T, Hardouin A, Riviere A, Milano G
Lien Pubmed
Résumé
Prospective studies of dose adaptation of continuous 5FU infusion combined with cisplatin have shown that pharmacologically guided dosing was feasible in the treatment of head and neck carcinomas. Adaptative dosing results in reduced haematological toxicity, but few data are available for clinical response rate. Preliminary results (38 patients) of a randomized trial comparing standard dose of 5FU (20 patients) and monitoring of 5FU based on pharmacokinetic information (half-cycle area under the curve, 18 patients) indicate that haematological tolerance and complete response rate were improved. Severe (GIII-GIV) thrombocytopenia and neutropenia were significantly reduced during cycle 2 (0% versus 11.1% and 5.5% versus 27.7% respectively, p < 0.01) and cycle 3 (0% versus 27.7% and 6.6% versus 33.3% respectively, p < 0.001). The complete response rate was increased in the group with monitoring of 5FU doses (55.5% versus 40.0%, p < 0.001). These interesting results will be confirmed at the end of the trial, which is expected to include 126 patients.
Mots clés
Adult, Aged, Carcinoma, Squamous Cell, drug therapy, Dose-Response Relationship, Drug, Drug Administration Schedule, Female, Fluorouracil, administration & dosage, Head and Neck Neoplasms, drug therapy, Humans, Male, Metabolic Clearance Rate, Middle Aged, Neutropenia, chemically induced, Thrombocytopenia, chemically induced, Treatment Outcome
Référence
Anticancer Res.. ;14(6A):2347-52