Correlation between radio-induced lymphocyte apoptosis measurements obtained from two French centres.
Fiche publication
Date publication
juillet 2016
Journal
Cancer radiotherapie : journal de la Societe francaise de radiotherapie oncologique
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MERLIN Jean-Louis, Dr MIRJOLET Céline
Tous les auteurs :
Mirjolet C, Merlin JL, Dalban C, Maingon P, Azria D
Lien Pubmed
Résumé
In the era of modern treatment delivery, increasing the dose delivered to the target to improve local control might be modulated by the patient's intrinsic radio-sensitivity. A predictive assay based on radio-induced lymphocyte apoptosis quantification highlighted the significant correlation between CD4 and CD8 T-lymphocyte apoptosis and grade 2 or 3 radiation-induced late toxicities. By conducting this assay at several technical platforms, the aim of this study was to demonstrate that radio-induced lymphocyte apoptosis values obtained from two different platforms were comparable.
Mots clés
Apoptosis, France, Head and Neck Neoplasms, radiotherapy, Humans, Laboratories, Hospital, standards, Linear Models, Lymphocytes, pathology, Prospective Studies, Radiotherapy, adverse effects
Référence
Cancer Radiother. 2016 Jul;20(5):391-4