Comparison of Five Different Assays for the Detection of BRAF Mutations in Formalin-Fixed Paraffin Embedded Tissues of Patients with Metastatic Melanoma.
Fiche publication
Date publication
avril 2017
Journal
Molecular diagnosis & therapy
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HARLE Alexandre, Dr LEROUX Agnès, Pr MERLIN Jean-Louis
Tous les auteurs :
Franczak C, Salleron J, Dubois C, Filhine-Trésarrieu P, Leroux A, Merlin JL, Harlé A
Lien Pubmed
Résumé
Metastatic or unresectable melanoma is a serious and deadly disease. Anti-BRAF and immunotherapy improved overall survival in patients with metastatic disease. Thus, BRAF genotyping is important to choose the right therapy.
Mots clés
Alleles, DNA Mutational Analysis, methods, Female, Genotype, High-Throughput Nucleotide Sequencing, Humans, Immunohistochemistry, Male, Melanoma, genetics, Mutation, Neoplasm Metastasis, Neoplasm Staging, Polymerase Chain Reaction, Proto-Oncogene Proteins B-raf, genetics, Sensitivity and Specificity
Référence
Mol Diagn Ther. 2017 Apr;21(2):209-216