Exosomes and Other Extracellular Vesicles in HPV Transmission and Carcinogenesis.
Fiche publication
Date publication
août 2017
Journal
Viruses
Auteurs
Membres identifiés du Cancéropôle Est :
Dr HERMETET François, Pr PRETET Jean-Luc, Dr GUENAT David
Tous les auteurs :
Guenat D, Hermetet F, Prétet JL, Mougin C
Lien Pubmed
Résumé
Extracellular vesicles (EVs), including exosomes (Exos), microvesicles (MVs) and apoptotic bodies (ABs) are released in biofluids by virtually all living cells. Tumor-derived Exos and MVs are garnering increasing attention because of their ability to participate in cellular communication or transfer of bioactive molecules (mRNAs, microRNAs, DNA and proteins) between neighboring cancerous or normal cells, and to contribute to human cancer progression. Malignant traits can also be transferred from apoptotic cancer cells to phagocytizing cells, either professional or non-professional. In this review, we focus on Exos and ABs and their relationship with human papillomavirus (HPV)-associated tumor development. The potential implication of EVs as theranostic biomarkers is also addressed.
Mots clés
apoptotic bodies, carcinogenesis, cell-to-cell communication, exosomes, horizontal gene transfer, microvesicles, papillomavirus
Référence
Viruses. 2017 Aug;9(8):