Transport, stability, and biological activity of resveratrol.
Fiche publication
Date publication
janvier 2011
Journal
Annals of the New York Academy of Sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DELMAS Dominique, Pr GHIRINGHELLI François, Dr AIRES Virginie, Dr LIMAGNE Emeric
Tous les auteurs :
Delmas D, Aires V, Limagne E, Dutartre P, Mazué F, Ghiringhelli F, Latruffe N
Lien Pubmed
Résumé
Numerous studies have reported interesting properties of trans-resveratrol, a phytoalexin, as a preventive agent of several important pathologies: vascular diseases, cancers, viral infections, and neurodegenerative processes. These beneficial effects of resveratrol have been supported by observations at the cellular and molecular levels in both cellular and in vivo models, but the cellular fate of resveratrol remains unclear. We suggest here that resveratrol uptake, metabolism, and stability of the parent molecule could influence the biological effects of resveratrol. It appears that resveratrol stability involves redox reactions and biotransformation that influence its antioxidant properties. Resveratrol's pharmacokinetics and metabolism represent other important issues, notably, the putative effects of its metabolites on pathology models. For example, some metabolites, mainly sulfate-conjugated resveratrol, show biological effects in cellular models. The modifications of resveratrol stability, chemical structure, and metabolism could change its cellular and molecular targets and could be crucial for improving or decreasing its chemopreventive properties.
Mots clés
Animals, Antioxidants, metabolism, Biological Transport, Active, physiology, Cell Membrane, metabolism, Humans, Membrane Transport Proteins, metabolism, Stilbenes, metabolism
Référence
Ann. N. Y. Acad. Sci.. 2011 Jan;1215:48-59