Targeting the Tumor Microenvironment: The Protumor Effects of IL-17 Related to Cancer Type.
Fiche publication
Date publication
août 2016
Journal
International journal of molecular sciences
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GARBAR Christian, Pr MERROUCHE Yacine, Pr BENSUSSAN Armand
Tous les auteurs :
Fabre J, Giustiniani J, Garbar C, Antonicelli F, Merrouche Y, Bensussan A, Bagot M, Al-Dacak R
Lien Pubmed
Résumé
The inflammatory process contributes to immune tolerance as well as to tumor progression and metastasis. By releasing extracellular signals, cancerous cells constantly shape their surrounding microenvironment through their interactions with infiltrating immune cells, stromal cells and components of extracellular matrix. Recently, the pro-inflammatory interleukin 17 (IL-17)-producing T helper lymphocytes, the Th17 cells, and the IL-17/IL-17 receptor (IL-17R) axis gained special attention. The IL-17 family comprises at least six members, IL-17A, IL-17B, IL-17C, IL-17D, IL-17E (also called IL-25), and IL-17F. Secreted as disulfide-linked homo- or heterodimers, the IL-17 bind to the IL-17R, a type I cell surface receptor, of which there are five variants, IL-17RA to IL-17RE. This review focuses on the current advances identifying the promoting role of IL-17 in carcinogenesis, tumor metastasis and resistance to chemotherapy of diverse solid cancers. While underscoring the IL-17/IL-17R axis as promising immunotherapeutic target in the context of cancer managing, this knowledge calls upon further in vitro and in vivo studies that would allow the development and implementation of novel strategies to combat tumors.
Mots clés
Animals, Humans, Immunotherapy, methods, Interleukin-17, genetics, Neoplasms, classification, T-Lymphocytes, Helper-Inducer, immunology, Tumor Microenvironment, immunology
Référence
Int J Mol Sci. 2016 Aug;17(9):