A phenotypic and mechanistic perspective on heterogeneity of HER2-positive breast cancers.
Fiche publication
Date publication
janvier 2016
Journal
Molecular & cellular oncology
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PIVOT Xavier
Tous les auteurs :
Ferrari A, Sertier AS, Vincent-Salomon A, Pivot X, Pauporté I, Saintigny P, Birnbaum D, Viari A
Lien Pubmed
Résumé
Analysis of gene expression and whole-genome features of 64 human epidermal growth factor 2 (HER2)-positive breast tumors supports the idea that their intrinsic heterogeneity actually reflects their cell of origin, suggesting that HER2 amplification is an embedded event in the natural history of these tumors. Possible mechanisms for this event involve breakage-fusion-bridge and chromothripsis.
Mots clés
Breakage-Fusion-Bridge, Breast cancer, ERBB2 amplification, cancer genomics, mammary epithelial hierarchy
Référence
Mol Cell Oncol. 2016 ;3(6):e1232186