Assessment of the prognostic role of a 94-single nucleotide polymorphisms risk score in early breast cancer in the SIGNAL/PHARE prospective cohort: no correlation with clinico-pathological characteristics and outcomes.
Fiche publication
Date publication
août 2017
Journal
Breast cancer research : BCR
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FUMOLEAU Pierre, Dr PAGET-BAILLY Sophie, Pr PETIT Thierry, Pr PIVOT Xavier, Dr RIOS Maria, Dr JOUANNAUD Christelle
Tous les auteurs :
Curtit E, Pivot X, Henriques J, Paget-Bailly S, Fumoleau P, Rios M, Bonnefoi H, Bachelot T, Soulié P, Jouannaud C, Bourgeois H, Petit T, Tennevet I, Assouline D, Mathieu MC, Jacquin JP, Lavau-Denes S, Darut-Jouve A, Ferrero JM, Tarpin C, Lévy C, Delecroix V, Trillet-Lenoir V, Cojocarasu O, Meunier J, Pierga JY, Kerbrat P, Faure-Mercier C, Blanché H, Sahbatou M, Boland A, Bacq D, Besse C, Thomas G, Deleuze JF, Pauporté I, Romieu G, Cox DG
Lien Pubmed
Résumé
Genome-wide association studies (GWAS) have to date identified 94 genetic variants (single nucleotide polymorphisms (SNPs)) associated with risk of developing breast cancer. A score based on the combined effect of the 94 risk alleles can be calculated to measure the global risk of breast cancer. We aimed to test the hypothesis that the 94-SNP-based risk score is associated with clinico-pathological characteristics, breast cancer subtypes and outcomes in early breast cancer.
Mots clés
Breast cancer, Genetic variant, Prognosis, Risk score, Single nucleotide polymorphism
Référence
Breast Cancer Res.. 2017 Aug;19(1):98