[Prognostic factors in operable epidermoid esophageal cancers]
Fiche publication
Date publication
février 1998
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WORONOFF Anne-Sophie
Tous les auteurs :
Woronoff AS, Mercier M, Gignoux M, Triboulet JP, Chaillard G, Bosset JF
Lien Pubmed
Résumé
OBJECTIVE: The aims of the study were to determine the prognostic factors on overall survival in patients with resectable squamous cell esophageal carcinoma. POPULATION: Two hundred and ninety three patients with stage I and II tumor were included in a phase III clinical trial that compared surgery alone to preoperative chemoirradiation. Eighteen parameters issued from clinical, biological radiological and pathological characteristics were included in univariate and multivariate analysis. RESULTS: The overall survival was influenced by: quality of surgical resection tumor response, nodal involvement on the CT-scan, tumor length and tumor location. Three groups of patients could be identified on two simple clinical preoperative variables. The first group: patients without dysphagia with or without nodal involvement on the CT-scan. The second group: patients with dysphagia and without nodal involvement on the CT-scan. The third group: patients with dysphagia and with nodal involvement with CT-scan. The 5 years survival rates were 34% for the first group, 23% for the second group and 0% for the third group. CONCLUSION: The identification of prognostic factors is valuable for the stratification of patients in future therapeutic studies.
Référence
Gastroenterol Clin Biol. 1998 Feb;22(2):168-74.