Templated assembly of albumin-based nanoparticles for simultaneous gene silencing and magnetic resonance imaging.
Fiche publication
Date publication
octobre 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BAUMERT Thomas, Dr VOEGEL Jean-Claude, Dr MERTZ Damien
Tous les auteurs :
Mertz D, Affolter-Zbaraszczuk C, Barthes J, Cui J, Caruso F, Baumert TF, Voegel JC, Ogier J, Meyer F
Lien Pubmed
Résumé
In this article, we address the design of innovative human serum albumin (HSA)-based nanoparticles loaded with silencing RNA and grafted with gadolinium complexes having average sizes ranging from ca. 50 to 150 nm according to the siRNA/HSA composition. The non-covalent siRNA/HSA assembly is formed on isobutyramide-modified mesoporous silica and the self-supported HSA-based nanoparticles are obtained following the silica template dissolution. These original protein particles provide simultaneous magnetic resonance imaging contrast enhancement and cellular in vitro gene silencing.
Référence
Nanoscale. 2014 Oct 21;6(20):11676-80