Chrysopentamine, an antiplasmodial anhydronium base from Strychnos usambarensis leaves.
Fiche publication
Date publication
janvier 2004
Auteurs
Membres identifiés du Cancéropôle Est :
Dr NUZILLARD Jean-Marc
Tous les auteurs :
Frederich M, Cristino A, Choi YH, Verpoorte R, Tits M, Angenot L, Prost E, Nuzillard JM, Zeches-Hanrot M
Lien Pubmed
Résumé
A new derivative of strychnopentamine was isolated from the leaves of Strychnos usambarensis. This compound, named chrysopentamine, was identified by detailed spectroscopic methods (UV, IR, HR-ESI-MS, 1D and 2D NMR). Chrysopentamine presented an original hydroxy substitution on C-14 and an aromatization of the ring D of strychnopentamine leading to anhydronium base properties and exhibited strong antiplasmodial properties (IC (50) less than 1 microM).
Référence
Planta Med. 2004 Jan;70(1):72-6.