Retinoic-acid-induced apoptosis in leukemia cells.
Fiche publication
Date publication
octobre 2004
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GRONEMEYER Hinrich
Tous les auteurs :
Jimenez-Lara AM, Clarke N, Altucci L, Gronemeyer H
Lien Pubmed
Résumé
Retinoic acid (RA) cures more than 75% of patients with acute promyelocytic leukemia (APL). Here, we review the various anti-cancer activities of retinoids and rexinoids, alone and in combination with other drugs, with emphasis on the RA-dependent induction of a cancer-cell-selective apoptosis signaling pathway to which multiple anti-cancer signals converge. These findings identify the TRAIL (tumor-necrosis-factor-related apoptosis-inducing ligand) pathway as a central cell-autonomous anti-cancer weapon that can act independently of the immune system.
Référence
Trends Mol Med. 2004 Oct;10(10):508-15.