Segregation of chromosomes in sperm of Robertsonian translocation carriers.
Fiche publication
Date publication
janvier 2005
Auteurs
Membres identifiés du Cancéropôle Est :
Pr ROUX Christophe
Tous les auteurs :
Roux C, Tripogney C, Morel F, Joanne C, Fellmann F, Clavequin MC, Bresson JL
Lien Pubmed
Résumé
Robertsonian translocations are the most frequent structural chromosomal abnormalities in humans and can affect fertility, with various degrees of sperm alterations in men; or the pregnancy outcome of the carriers. The studies on meiotic segregation of chromosomes in sperm of Robertsonian translocation males find a majority of normal or balanced spermatozoa for the chromosomes related to the translocation (mean 85.42%; range 60-96.60%). Furthermore, recent studies suggest an interchromosomal effect. Studies on spermatozoa from translocation carriers, and in mouse models help the comprehension of the meiotic segregation mechanisms. Results of meiotic segregation analysis in man could be integrated in genetic counselling especially when assisted reproductive technology is required.
Référence
Cytogenet Genome Res. 2005;111(3-4):291-6.