B Cell allogeneic responses after hematopoietic cell transplantation: is it time to address this issue?
Fiche publication
Date publication
février 2005
Auteurs
Membres identifiés du Cancéropôle Est :
Dr PERRUCHE Sylvain
Tous les auteurs :
Perruche S, Kleinclauss F, Tiberghien P, Saas P
Lien Pubmed
Résumé
To date, B cell responses have retained less attention than T, natural killer or dendritic cell responses in the alloreactive conflict after allogeneic hematopoietic cell transplantation (HCT). Here, we discuss recent clinical and experimental data supporting a role of allogeneic B cell responses in graft-host interactions after HCT. We report results in a murine model of reduced intensity conditioning transplantation (RICT) showing that host B cells can be involved in chronic graft-versus-host disease occurrence. We also describe the control of antidonor alloresponses by intravenous simultaneous infusion of apoptotic cells with allogeneic hematopoietic grafts.
Référence
Transplantation. 2005 Feb 15;79(3 Suppl):S37-9.