Fatal stimulation of acute myeloid leukemia blasts by pegfilgrastim.
Fiche publication
Date publication
novembre 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr HERBRECHT Raoul, Pr MAUVIEUX Laurent
Tous les auteurs :
Duval C, Boucher S, Moulin JC, Gourieux B, Mauvieux L, Leveque D, Herbrecht R
Lien Pubmed
Résumé
We herein report the case of a male patient with acute myeloid leukemia with fatal outcome attributable to pharmacokinetics of pegfilgrastim. CASE REPORT: An unexplained blast proliferation in a patient with acute myeloid leukemia following cytotoxic induction chemotherapy was investigated in depth. Myeloblast hyperstimulation was likely related to pegfilgrastim, the long half-life of which extended the duration of side-effects, resulting in massive and rapidly fatal leukemia cell proliferation. CONCLUSION: Pegfilgrastim can cause unexpected deleterious effects in acute myeloid leukemia. We, thus, recommend administering drugs with a shorter half-life, such as filgrastim or lenograstim, to reduce infection incidence in patients receiving myelosuppressive chemotherapy associated with a clinically significant incidence of febrile neutropenia.
Référence
Anticancer Res. 2014 Nov;34(11):6747-8.