Hypermetabolism during resting-state FDG-PET suggesting intrinsic epileptogenicity in focal cortical dysplasia.
Fiche publication
Date publication
novembre 2014
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques
Tous les auteurs :
Namer IJ, Valenti-Hirsch MP, Scholly J, Lannes B, Imperiale A, Hirsch E
Lien Pubmed
Résumé
We report the case of a 21-year-old man who presented drug-resistant epilepsy since the age of 3 years. The underlying type Ia left prefrontal focal cortical dysplasia was revealed by focal hypermetabolism of FDG-PET several years later. The stereo-electroencephalography showed continuous interictal rhythmic spike discharges, suggesting the dysplastic character of the cortex explored by depth electrodes placed into and at the margins of PET abnormalities. The surgical limits of resection were defined based on interictal activity, spontaneous and induced seizures. The patient is seizure-free, with normal electroencephalography and clear improvement of neuropsychological performance, without functional deficit at 3 years postsurgery.
Référence
Clin Nucl Med. 2014 Nov;39(11):993-5