Interleukin-1beta (IL-1beta) induces a crosstalk between cAMP and ceramide signaling pathways in thyroid epithelial cells.
Fiche publication
Date publication
décembre 2005
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MARTINY Laurent, Dr SCHNEIDER Christophe, Dr EL BTAOURI Hassan
Tous les auteurs :
Schneider C, Rath GM, Delorme N, El Btaouri H, Hornebeck W, Martiny L
Lien Pubmed
Résumé
Interleukin-1 beta (IL-1beta) is an important regulator of the thyroid cell function. This cytokine has been largely described to trigger an important biological signaling cascade: the sphingomyelin/ceramide pathway. In this report, we show that IL-1beta induces the transient activation of a neutral sphingomyelinase in porcine thyroid cells. Moreover, IL-1beta and ceramides are demonstrated to inhibit the TSH-induced cAMP production via the implication of alphaGi subunit of the adenylyl cyclase system. This crosstalk between cAMP and ceramide pathways constitutes a preponderant process in the TSH-controlled differentiation state of thyrocytes. All these results argue for the involvement of ceramides and IL-1beta in the thyroid function regulation, leading to a cell dedifferentiated state.
Référence
Biochimie. 2005 Dec;87(12):1121-6