Interaction forces of a supported DOPC bilayer in the presence of the general anaesthetic halothane - An atomic force microscopy study.
Fiche publication
Date publication
janvier 2006
Auteurs
Membres identifiés du Cancéropôle Est :
Pr FINOT Eric
Tous les auteurs :
Shamrakov LG, Leonenko ZV, Finot E, Cramb DT
Lien Pubmed
Résumé
In this study atomic force microscopy (AFM) was used to study the effect of halothane on a supported dioleoylphosphatidylcholine ( DOPC) bilayer under conditions of high anaesthetic loading. In a previous study we demonstrated that bilayer restructuring occurs as a result of halothane incorporation. Force measurements using AFM indicate an initial decrease in adhesive forces and compressibility between the bilayer and AFM tip, followed by an increase in adhesion properties as a function of incubation time. This effect is attributed to the location and dynamic redistribution of halothane within the bilayer.
Référence
Aust J Chem. 2006;59(6):386-9.