Short and efficient preparations of isoxazole-3-carboxylic acid and imino-oxopentanoic acid potent precursors of 4-hydroxyisoleucine.
Fiche publication
Date publication
mai 2006
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain
Tous les auteurs :
Becht JM, Marin SD, Maruani M, Wagner A, Mioskowski C
Lien Pubmed
Résumé
Herein, we describe short and efficient syntheses of isoxazole-3-carboxylic acid 3a and imino-oxopentanoic acid 8 achiral precursors of 4-hydroxyisoleucine. The developed procedures involve readily available and cheap starting materials and can easily be transposed to the large scale. (c) 2006 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron. 2006 May 1;62(18):4430-4.