Gold-phosphine-porphyrin as potential metal-based theranostics.
Fiche publication
Date publication
janvier 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GAIDDON Christian, Pr PAUL Catherine
Tous les auteurs :
Tasan S, Licona C, Doulain PE, Michelin C, Gros CP, Le Gendre P, Harvey PD, Paul C, Gaiddon C, Bodio E
Lien Pubmed
Résumé
Two new gold-phosphine-porphyrin derivatives were synthesized and fully characterized, and their photophysical properties investigated along a water-soluble analog. The cytotoxicity of the compounds was tested on cancer cells (HCT116 and SW480), and their cell uptake was followed by fluorescence microscopy in vitro (on SW480). The proof that the water-soluble gold-phosphine-porphyrin is a biologically active compound that can be tracked in vitro was clearly established, especially concerning the water-soluble analog. Some preliminary photodynamic therapy (PDT) experiments were also performed. They highlight a dramatic increase of the cytotoxicity when the cells were illuminated for 30 min with white light.
Référence
J Biol Inorg Chem. 2015 Jan;20(1):143-54