Divergent synthesis of novel unsymmetrical dendrons containing photosensitizing units.
Fiche publication
Date publication
décembre 2006
Auteurs
Membres identifiés du Cancéropôle Est :
Pr BARBERI-HEYOB Muriel, Dr FROCHOT Céline, Pr SCHNEIDER Raphaël
Tous les auteurs :
Morosini V, Frochot C, Barberi-Heyob M, Schneider R
Lien Pubmed
Résumé
The synthesis, characterization and singlet oxygen quantum yield of novel unsymmetrical dendrons containing photosensitizing units at their periphery is reported. Boc-protected 2,2'-(ethylenedioxy)-bis-ethylamine reacted with methyl acrylate and ethylene diamine to give half-dendrimers 4 and 5 with 2 and 4 end groups, respectively. Amine-tethered porphyrins and compounds 4 and 5 were efficiently coupled in DMF at 100 degrees C to give the functionalized dendrons. UV-visible and fluorescence emission spectra showed that the photophysical properties of the porphyrins were retained in the dendrimers. (c) 2006 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron Lett. 2006 Dec 4;47(49):8745-9.