Bioactive coatings based on polyelectrolyte multilayer architectures functionalized by embedded proteins, peptides or drugs.
Fiche publication
Date publication
février 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BENKIRANE-JESSEL Nadia, Dr VOEGEL Jean-Claude
Tous les auteurs :
Leguen E, Chassepot A, Decher G, Schaaf P, Voegel JC, Jessel N
Lien Pubmed
Résumé
In recent years, considerable effort has been devoted to the design and controlled fabrication of structured materials with functional properties. The layer by layer buildup of polyelectrolyte multilayer films (PEM films) from oppositely charged polyelectrolytes offers new opportunities for the preparation of functionalized biomaterial coatings. This technique allows the preparation of supramolecular nano-architectures exhibiting specific properties in terms of control of cell activation and may also play a role in the development of local drug delivery systems. Peptides, proteins, chemically bound to polyelectrolytes, adsorbed or embedded in PEM films, have been shown to retain their biological activities.
Référence
Biomol Eng. 2007 Feb;24(1):33-41