[Microarray-based comparative genomic hybridization in the study of constitutional chromosomal abnormalities]
Fiche publication
Date publication
février 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Pr CHAMBON Pierre
Tous les auteurs :
Beri-Dexheimer M, Bonnet C, Chambon P, Brochet K, Gregoire MJ, Jonveaux P
Lien Pubmed
Résumé
Chromosomal aberrations are the first cause of mental impairment and dysmorphism. Rearrangements involving large chromosomal segments can be detected by standard chromosome analysis using GTG-banding, but this technique is not suited for the detection of small chromosome abnormalities. Array comparative genomic hybridisation (array-CGH) is a method used to detect segmental DNA copy number alterations. Recently, advances in this technology have enabled high-resolution examination for identifying genetic alterations and copy number variations on a genome-wide scale. This review describes the current genomic array platforms and CGH methodologies and highlights their applications for studying constitutional disease.
Référence
Pathol Biol (Paris). 2007 Feb;55(1):13-8