Design, synthesis and evaluation of a novel polymer for gene delivery to mammalian cells
Fiche publication
Date publication
mars 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ZUBER Guy
Tous les auteurs :
Chittimalla C, Dalkara D, Zuber G
Lien Pubmed
Résumé
We rationally designed and synthesized a novel cationic polymer with intrinsic endosomolytic properties based on a semi-peptide monomer bridged by disulfide bonds. This polymer was shown to associate with DNA and to form polyplexes with gene transfection activity without addition of chloroquine, a known endosomolytic agent.
Référence
Lett Drug Des Discov. 2007 Mar;4(2):92-8