Mixed oxazoline-carbenes as stereodirecting ligands for asymmetric catalysis.
Fiche publication
Date publication
mars 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELLEMIN-LAPONNAZ Stéphane
Tous les auteurs :
Gade LH, Bellemin-Laponnaz S
Lien Pubmed
Résumé
Whereas initially the use of chiral N-heterocyclic carbene (NHC) ligands in asymmetric catalysis met with very limited success, several novel structural concepts have emerged which have led to a rapid expansion of the field since the beginning of this decade. One concept in the design of new chiral NHC-containing molecular catalysts is the incorporation of oxazolines. These may play a secondary structural role in the design of monodentate chiral NHCs which are either employed as organocatalysts or as stereodirecting spectator ligands in transition metal complexes. Alternatively, oxazolines may be ligating units which are combined with NHCs to give polydentate stereodirecting ligands. Both approaches have been applied successfully and are reviewed in this article. (c) 2006 Elsevier B.V. All rights reserved.
Référence
Coord Chem Rev. 2007 Mar;251(5-6):718-25.