Discovery and development of therapeutic cancer vaccines
Fiche publication
Date publication
mars 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Dr LIMACHER Jean-Marc
Tous les auteurs :
Acres B, Limacher JM, Bonnefoy JY
Lien Pubmed
Résumé
Over the past century, various efforts have been made to induce the rejection of cancerous tissues by the stimulation of an immune reaction, using both non-specific and antigen-specific strategies. Non-specific approaches attempt to augment an immune response in and around the tumor by injecting immune stimulating substances, for example, bacterial extracts, cytokines or gene therapy agents. Antigen-specific approaches use either the tumor cells themselves as a source of antigens or incorporate identified tumor-associated antigens into vaccines. This review describes antigen-specific therapeutic cancer vaccines that are currently in development.
Référence
Curr Opin Drug Discov Devel. 2007 Mar;10(2):185-92.