Reinforcing effect of bi- and tri-cyclopolyprenols on 'primitive' membranes made of polyprenyl phosphates
Fiche publication
Date publication
avril 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DESAUBRY Laurent, Dr ELHABIRI Mourad
Tous les auteurs :
Ribeiro N, Streiff S, Heissler D, Elhabiri M, Albrecht-Gary AM, Atsumi M, Gotoh M, Desaubry L, Nakatani Y, Ourisson G
Lien Pubmed
Résumé
Cholesterol plays the role of membrane reinforcer in eukaryotes, whereas hopanoids play the same role in bacteria. Which components could have reinforced 'primitive' membranes? We describe here an efficient biomimetic synthesis of bi- and tri-cyclopolyprenols and demonstrate that these compounds reinforce the membranes of polyprenyl phosphate, which we speculated as 'primitive' membranes. (c) 2007 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron. 2007 Apr 16;63(16):3395-407.