Synthesis of biaryls via decarboxylative Pd-catalyzed cross-coupling reaction.
Fiche publication
Date publication
avril 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain
Tous les auteurs :
Becht JM, Catala C, Drian CL, Wagner A
Lien Pubmed
Résumé
[reaction: see text] A simple and efficient route to biaryls via Pd-catalyzed decarboxylative cross-couplings of arene carboxylic acids and aryl iodides is reported. The PdCl2/AsPh3 catalytic system in the presence of Ag2CO3 in DMSO was found to be particularly efficient to perform this transformation. This reaction can be extended to the synthesis of various biaryls, including sterically hindered biaryls, with yields ranging from 58% to 90%.
Référence
Org Lett. 2007 Apr 26;9(9):1781-3