[Good clinical practices and inpatient antibiotics: optimization of fluoroquinolone switch therapy]
Fiche publication
Date publication
septembre 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GUIGNARD Marie-Hélène
Tous les auteurs :
Rigaud B, Malbranche C, Pioud V, Lochard A, Chemelle M, Aube H, Lazzarotti A, Guignard MH
Lien Pubmed
Résumé
OBJECTIVE: Intravenous-to-oral switch therapy is strongly recommended in the medical literature. The aim of this study was to assess how we can improve fluoroquinolone switch therapy. METHODS: In this comparative prospective study, we analyzed 243 intravenous ciprofloxacin treatments and assessed the impact of promoting a switch to oral step-down therapy. RESULTS: This study found that switches from intravenous to oral therapy increased, mainly in medical wards, and led to significant savings in direct costs. DISCUSSION: Promoting switch therapy has improved clinical practices in antibiotic use and led to lower direct and probably indirect drug-related costs. CONCLUSION: Our findings will help define the role of switch therapy in improving clinical practices in inpatient antibiotic use.
Référence
Presse Med. 2007 Sep;36(9 Pt 1):1159-66