Epidemiology of hepatocellular carcinoma in Bas-Rhin: analysis of all incident cases from 1990 to 1999
Fiche publication
Date publication
octobre 2007
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VELTEN Michel
Tous les auteurs :
Binder-Foucard F, Doffoel M, Velten M
Lien Pubmed
Résumé
In France, primary liver cancer - essentially represented by hepa tocellular carcinoma - ranks 8(th) among the cancers in men, and incidence rates are increasing. The present study describes the epidemiological characteristics of hepatocellular carcinoma in Bas-Rhin (lower Rhine region of Alsace) between 1990 and 1999. All the incident cases of hepatocellular carcinoma recorded in the cancer registry of Bas-Rhin between January 1(st) 1990 and December 3 1(st) 1999 were studied. incidence rates were standardized on the world population, using the direct method. Survival was studied with the Kaplan-Meier method and a multivariate analysis was performed using the Cox model. A total of 845 cases of hepatocellular carcinoma were recorded. The incidence of hepatocellular carcinoma (histologically verified or not) remained stable over the whole period. The proportion of cases with underling viral cirrhosis rose from 9% for the 1990-91 period up to 2 or the 1998-99 period (p=0.043). Overall survival after one year reached 35%. In multivariate analysis, the following variables were significantly related to survival: cirrhosis, Child-Pugh score, alphafoetoprotein level, type of tumour, portal vein thrombosis and type of treatment.
Référence
Gastroenterol Clin Biol. 2007 Oct;31(10):838-43.