Evaluation of the ability of an organic derivative of ruthenium(II) to reinforce the cytotoxicity of fast neutron against malignant cells in culture
Fiche publication
Date publication
janvier 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Dr GAIDDON Christian, Dr LOEFFLER Jean-Philippe
Tous les auteurs :
Leyva L, Malek F, Benzina S, Denis JM, Gueulette J, Dufour P, Gaiddon C, Loeffler JP, Sirlin C, Pfeffer M, Bischoff P
Lien Pubmed
Résumé
The effect of combining RDC-11 (a new ruthenium organometallic complex) and fast neutrons (high-LET radiations) has been evaluated in RDM4 and U-87 tumor cell lines. After co-treatment, a substantial reduction of cell growth was recorded, which appears not to be correlated with the induction of apoptosis.
Référence
Lett Drug Des Discov. 2008 Jan;5(1):1-6