Metastatic breast cancers
Fiche publication
Date publication
février 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Pr PETIT Thierry
Tous les auteurs :
Campone M, Deplanque G, Dohollou N, Gligorov J, Largillier R, Namer M, Penault-Llorca E, Petit T, Spielmann M, Zelek L
Lien Pubmed
Résumé
Although the treatment of early breast cancer is relatively well-defined, therapeutic options for metastatic breast cancer remains controversial. The published guidelines for the management of metastatic breast cancer mainly aim to draw up a list of available agents and treatments according to menopausal status and hormone receptors (HR). Taking into account all the variables influencing therapeutic decision-making, the purpose of the present study was to find a consensus with respect to patients with metastatic breast cancer. The selected prognostic factors were disease-free duration, visceral metastasis, HR, and possibly LDH. The validated predictive factors of response to treatment were HR and HER2 status. The choice of these predictive factors as well as the disease's level of aggressiveness were the basis for the choice of first-line treatment i.e. chemotherapy (mono- or poly-chemotherapy, concomitant or sequential), hormonotherapy, or chemoendocrine therapy.
Référence
Oncologie. 2008 Feb;10(2):136-48