6(th) international symposium on retroviral nucleocapsid
Fiche publication
Date publication
février 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Pr MELY Yves
Tous les auteurs :
Berkhout B, Gorelick R, Summers MF, Mely Y, Darlix JL
Lien Pubmed
Résumé
Retroviruses and LTR-retrotransposons are widespread in all living organisms and, in some instances such as for HIV, can be a serious threat to the human health. The retroviral nucleocapsid is the inner structure of the virus where several hundred nucleocapsid protein (NC) molecules coat the dimeric, genomic RNA. During the past twenty years, NC was found to play multiple roles in the viral life cycle (Fig. 1), notably during the copying of the genomic RNA into the proviral DNA by viral reverse transcriptase and integrase, and is therefore considered to be a prime target for anti-HIV therapy. The 6(th) NC symposium was held in the beautiful city of Amsterdam, the Netherlands, on the 20(th) and 21(st) of September 2007. All aspects of NC biology, from structure to function and to anti-HIV vaccination, were covered during this meeting.
Référence
Retrovirology. 2008 Feb 25; 5: