Irradiation adaptation to tumor activity with the help of intensity-modulated radiation therapy for head and neck cancers. Preliminary study on phantoms
Fiche publication
Date publication
mars 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Pr WOLF Didier
Tous les auteurs :
Kubs F, Aletti P, Wolf D, Millasseau S, Marchesi V
Lien Pubmed
Résumé
The aim of this study was to index delivered doses of irradiation to tumor activity and not only to tumor geometry. The elaboration of a new highly precise treatment protocol, based on tumor activity required a specific configuration in order to use this type of irradiation. Using a Treatment Planning System and two head and neck phantoms specially created, we have performed system characterization according to different treatment plans. Two models were created and used: a simplistic and an anatomical model. Our results showed that high-precision radiotherapy in limited zones is possible with intensity modulated radiation therapy when several conditions are met such as location, number of organs at risk, distance between Planning Target Volume and organs at risk, presence, volume and location of the tumor activity, number of fields. In order to use this irradiation method adapted to the tumor activity, a precise geometry will be necessary. However such high total and fractionated doses should be carefully evaluated before being prescribed clinically. (C) 2008 Elsevier Masson SAS. Tous droits reserves.
Référence
Irbm. 2008 Mar;29(1):25-34