LRP-1: a new modulator of cytoskeleton dynamics and adhesive complex turnover in cancer cells.
Fiche publication
Date publication
avril 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DEDIEU Stéphane, Dr LANGLOIS Benoît
Tous les auteurs :
Dedieu S, Langlois B
Lien Pubmed
Résumé
The low-density lipoprotein receptor-related protein-1 (LRP-1)is a large scavenger receptor mediating the internalization and catabolism of various biological components from the extracellular matrix. In the past decade, LRP-1 appeared as an attractive receptor for targeting the invasive behavior of cancer cells since this protein is able to reduce the accumulation of extracellular proteinases by endocytosis. However, recent data suggest that LRP-1 could support carcinoma cell invasion depending on the cellular environment. Indeed, in addition to its well-determined role in ligand binding and endocytosis, LRP-1 emerges as a central molecular regulator of cytoskeleton organization and adhesive complex turnover in malignant cells. This commentary reviews the functions played by LRP-1 in cancer-related events and discusses the potential mechanisms whereby LRP-1 is able to control the cellular phenotype of cancer cells.
Référence
Cell Adh Migr. 2008 Apr;2(2):77-80.