Solid-phase synthesis of tetrasubstituted 2-imino-1,3-thiazolines using a functionalizing cleavage strategy
Fiche publication
Date publication
avril 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Dr WAGNER Alain
Tous les auteurs :
Gomez L, Gellibert F, Wagner A, Mioskowski C
Lien Pubmed
Résumé
A novel solid-phase synthesis of tetrasubstituted 2-imino-1,3-thiazolines using a functionalizing cleavage strategy is described. The synthetic route utilized the ambident reactivity of a dithiocarbamate functionality to synthesize the key resin-bound electrophilic thiazoliurn intennediate. The desired products were efficiently obtained in high purity by the reaction of various arnines with the thiazoliurn salt. (c) 2008 Elsevier Ltd. All rights reserved.
Référence
Tetrahedron Lett. 2008 Apr 21;49(17):2726-9