A practical concept for the kinetic resolution of a chiral secondary alcohol based on a polymeric silane.
Fiche publication
Date publication
mai 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Dr BELLEMIN-LAPONNAZ Stéphane
Tous les auteurs :
Issenhuth JT, Dagorne S, Bellemin-Laponnaz S
Lien Pubmed
Résumé
The paper describes our preliminary studies on the use of PMHS as a functionalizable polymer and hydride source for the kinetic resolution of secondary alcohols via chiral Cu(I)-catalyzed dehydrogenative silylating process. The chiral phosphine that chelates the Cu metal center has little influence on the selectivity factor of the kinetic resolution. The use of a stereogenic silane appears to be a key requirement to reach enantiodifferentiation in such a process. (C) 2008 Elsevier B.V. All rights reserved.
Référence
J Mol Catal A-chem. 2008 May 1;286(1-2):6-10.