What next for preimplantation genetic screening? More randomized controlled trials needed?
Fiche publication
Date publication
décembre 2008
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VIVILLE Stéphane
Tous les auteurs :
Mastenbroek S, Scriven P, Twisk M, Viville S, Van der Veen F, Repping S
Lien Pubmed
Résumé
The recent debate on preimplantation genetic screening (PGS) has raised questions about its routine use in clinical practice. It has been suggested that the most effective way to resolve the debate about the usefulness of PGS is to perform more well-designed and well-executed randomized controlled trials (RCTs). However, in view of the lack of evidence for the effectiveness of PGS and the accumulating evidence for its harmfulness, it is our opinion that it is unethical to perform additional RCTs for the indication advanced maternal age using cleavage stage biopsy.
Référence
Hum Reprod. 2008 Dec;23(12):2626-8