Nuclear translocation of glutathione transferase omega is a progression marker in Barrett's esophagus
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Date publication
février 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Pr VISVIKIS Athanase
Tous les auteurs :
Piaggi S, Marchi S, Ciancia E, Debortoi N, Lazzarotti A, Saviozzi M, Raggi C, Fierabracci V, Visvikis A, Bisgaard HC, Casini AF, Paolicchi A
Lien Pubmed
Résumé
Barrett's esophagus (BE) represents a major risk factor for esophageal adenocarcinoma (AC). For this reason, patients with BE are subjected to a systematic endoscopic surveillance to detect initial evolution towards non-invasive neoplasia (NiN) and cancer, that eventually occurs only in a small fraction of BE patients. This study was aimed to investigate the possible role of glutathione-S-transferase-omega 1 (GSTO1), a recently discovered member of the glutathione-S-transferase family, as a progression marker in the Barrett's disease in order to improve the diagnosis of NiN in BE and to understand the mechanisms of the progression from BE to AC. We investigated the expression and subcellular localization of GSTO1 in biopsies from patients with BE and in human cancer cell lines subjected to heath shock treatment. A selective nuclear localisation of GSTO1 was found in 16/16 biopsies with low- or high-grade NiN, while it appeared in only 4/22 BE biopsies without signs of NiN (P
Référence
Oncol Rep. 2009 Feb;21(2):283-7.