Aortic inflammation, as assessed by hybrid FDG-PET/CT imaging, is associated with enhanced aortic stiffness in addition to concurrent calcification.
Fiche publication
Date publication
juin 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Pr DOLIVET Gilles
Tous les auteurs :
Joly L, Djaballah W, Koehl G, Mandry D, Dolivet G, Marie PY, Benetos A
Lien Pubmed
Résumé
PURPOSE: To analyse the relationship between: (i) aortic pulse wave velocity (PWV), an index of aortic stiffness with strong prognostic significance, and (ii) aortic calcification and inflammation, which were quantified by hybrid imaging with X-ray computed tomography (CT) and (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET). METHODS: Central aortic (carotid-femoral) and peripheral (carotid-brachial and femoral-tibial) PWV were recorded in 26 patients, who had been routinely referred for dual FDG-PET/CT imaging. RESULTS: In univariate analyses, central aortic PWV was strongly linked to the volume of calcifications (VCa) and an enhanced FDG activity, when determined by averaging standardized uptake values (SUV(max)). By multivariate stepwise analysis including age and gender, both VCa (p < 0.0001) and SUV(max) (p < 0.01) were significant determinants of PWV explaining 61% and 11% of its variability. CONCLUSION: Aortic inflammation, assessed by hybrid FDG-PET/CT imaging, is associated with an enhanced aortic stiffness, in addition to the concurrent impact of calcifications.
Référence
Eur J Nucl Med Mol Imaging. 2009 Jun;36(6):979-85