Homocysteine, vitamin B12, folate and cognitive functions: a systematic and critical review of the literature.
Fiche publication
Date publication
juillet 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Dr DALI-YOUCEF Nassim
Tous les auteurs :
Vogel T, Dali-Youcef N, Kaltenbach G, Andres E
Lien Pubmed
Résumé
Elevated serum homocysteine, decreased folate and low vitamin B(12) serum levels are associated with poor cognitive function, cognitive decline and dementia. Despite evidence of an epidemiological association, randomised controlled trials did not provide any clear evidence so far that supplementation with vitamin B(12) and/or folate improves dementia or slows cognitive decline, even though it might normalise homocysteine levels. In this report, we review the current knowledge on the relationship between homocysteine, folate and vitamin B(12) levels and the way their disruption influences cognitive function in adults.
Référence
Int J Clin Pract. 2009 Jul;63(7):1061-7.