Foreign accent syndrome as a first sign of multiple sclerosis.
Fiche publication
Date publication
septembre 2009
Auteurs
Membres identifiés du Cancéropôle Est :
Pr NAMER Izzie-Jacques, Pr DE SEZE Jérôme
Tous les auteurs :
Chanson JB, Kremer S, Blanc F, Marescaux C, Namer IJ, de Seze J
Lien Pubmed
Résumé
BACKGROUND: Foreign accent syndrome (FAS) consists of a speech rhythm disorder different from dysarthia or aphasia. It is unusually met in multiple sclerosis (MS). OBJECTIVE: We report a case of FAS as an initial symptom of a MS. METHODS: A right-handed French woman developed an isolated German foreign accent. Brain magnetic resonance imaging (MRI), SPECT and analysis of CSF were performed. RESULTS: Brain MRI revealed a large hypersignal on T2-weighted images in the left prerolandic white matter. Single photon emission computed tomography showed a right prerolandic hypoperfusion. Unmatched oligoclonal bands in cerebrospinal fluid and occurrence of new abnormal hypersignals on the following MRI led us to diagnose MS. CONCLUSION: FAS may be the first symptom of MS. It could result from extensive disturbances of brain function involving the right hemisphere.
Référence
Mult Scler. 2009 Sep;15(9):1123-5