Decrypthon grid - grid resources dedicated to neuromuscular disorders.
Fiche publication
Date publication
janvier 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr POCH Olivier
Tous les auteurs :
Bard N, Bolze R, Caron E, Desprez F, Heymann M, Friedrich A, Moulinier L, Nguyen NH, Poch O, Toursel T
Lien Pubmed
Résumé
Thanks to the availability of computational grids and their middleware, a seamless access to computation and storage resources is provided to application developers and scientists. The Decrypthon project is one example of such a high performance platform. In this paper, we present the architecture of the platform, the middleware developed to facilitate access to several servers deployed in France, and the data center for integrating large biological datasets over multiple sites, supported by a new query language and integration of various tools. The SM2PH project represents an example of a biological application that exploits the capacities of the Decrypthon grid. The goal of SM2PH is a better understanding of mutations involved in human monogenic diseases, their impact on the 3D structure of the protein and the subsequent consequences for the pathological phenotypes.
Référence
Stud Health Technol Inform. 2010;159:124-33.