Optimised NSAIDs-loaded Biocompatible Nanoparticles.
Fiche publication
Date publication
janvier 2010
Auteurs
Membres identifiés du Cancéropôle Est :
Dr ANDRY Marie-Christine
Tous les auteurs :
Roullin VG, Callewaert M, Molinari M, Delavoie F, Seconde A, Andry MC
Lien Pubmed
Résumé
In this formulation study, biocompatible non steroidal anti-inflammatory (NSAIDs)-loaded nanoparticles were designed as models to be further integrated in a prosthesis surface functionalization. A modified spontaneous emulsion-solvent diffusion methodology was used to produce drug-loaded PLGA nanoparticles without any purification or solvent evaporation requirements. Formulation parameters, such as lactide/glycolide ratio, polymer concentration, solvent/non solvent ratio and non solvent phase, as well as the non ionic tensioactive P188 co-precipitation composition were systematically explored. The optimized formulation (mean size: 145 nm, surface charge: -13 mV) was employed to encapsulate various amounts of NSAIDs in a simple and scalable manner. The drug release was characterized in vitro by a complete release for 48 h. These results encourage upcoming preliminary steps for in vivo experiments of prosthesis surface functionalization.
Référence
Nano-micro Lett. 2010;2(4):247-55.