Triterpenoid saponins from Albizia lebbeck (L.) Benth and their inhibitory effect on the survival of high grade human brain tumor cells.
Fiche publication
Date publication
mars 2015
Auteurs
Membres identifiés du Cancéropôle Est :
Pr GUILLAUME Dominique, Dr ZENIOU-MEYER Maria
Tous les auteurs :
Note OP, Jihu D, Antheaume C, Zeniou M, Pegnyemb DE, Guillaume D, Chneiwess H, Kilhoffer MC, Lobstein A
Lien Pubmed
Résumé
As part of our search of new bioactive triterpenoid saponins from Cameroonian Mimosaceae plants, phytochemical investigation of the roots of Albizia lebbeck led to the isolation of two new oleanane-type saponins, named lebbeckosides A-B (1-2). Their structures were established on the basis of extensive 1D and 2D NMR ((1)H, (13)C NMR, DEPT, COSY, TOCSY, ROESY, HSQC, and HMBC) and HRESIMS studies, and by chemical evidence. Compounds 1-2 were evaluated for their inhibitory effect on the metabolism of high grade human brain tumor cells, the human glioblastoma U-87 MG cell lines and the glioblastoma stem-like TG1 cells isolated from a patient tumor, and known to be particularly resistant to standard therapies. The isolated saponins showed significant cytotoxic activity against U-87 MG and TG1 cancer cells with IC50 values of 3.46 muM and 1.36 muM for 1, and 2.10 muM and 2.24 muM for 2, respectively.
Référence
Carbohydr Res. 2015 Mar 2;404:26-33